Shell and spatial structures: Between new developments and historical aspects

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Growth Charts for Height,Weight, and BMI (6–18 y) for the Tuscany Youth Sports Population

Overweight during youth is a large-scale public health issue. Engaging in regular physical activity generally reduces weight status. The hypothesis of the study is that organized sport plays an active role in maintaining a correct body weight during youth. The purpose of this study is to trace growth charts by height, weight, and body mass index (BMI) to be applied to the youth sports population. A retrospective study was conducted on 14,700 young athletes (10,469 males and 4231 females) aged between 6 and 18 years from surveillance carried out during the pre-participation screening of sports eligibility. The calculation of the prevalence of overweight and obesity was also performed. The new percentiles for the youth sports population show BMI values at 18 years 21.9 kg/m2 for males and 20.7 kg/m2 for females at the 50th percentile. The male sample shows 12.3% of the subjects were overweight and 1.5% were obese, while the female sample shows 9.8% are overweight and 1.1% obese. The higher prevalence of excess weight is evident up to 12 years old in both sexes and then gradually decreases. The development of the new specific growth charts for the youth sports population could reduce the risk of error in identifying the correct weight status of young athletes

Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation Electroanatomic characterization and treatment

ObjectivesThe purpose of this study was to evaluate the electroanatomic characteristics of left atrial tachycardia (AT) in a series of patients who underwent circumferential pulmonary vein ablation (CPVA) and to describe the ablation strategy and clinical outcome.BackgroundCircumferential pulmonary vein ablation is an effective treatment for atrial fibrillation. A potential midterm complication is the development of left AT. There are only isolated reports describing mapping and ablation of such arrhythmias.MethodsThirteen patients (age 57.4 ± 8.9 years, five female) underwent mapping and ablation of 14 left ATs via an electroanatomic mapping system a mean of 2.6 ± 1.6 months after CPVA.ResultsThree patients were characterized as having focal AT (cycle length: 266 ± 35.9 ms). Of 11 macro–re-entrant tachycardias studied in the remaining 10 patients (cycle length: 275 ± 75 ms), 5 showed single-loop and 6 dual-loop circuits. Re-entrant circuits used the mitral isthmus, the posterior wall, or gaps on previous encircling lines. Such gaps and all three foci occurred anterior to the left superior pulmonary vein or at the septal aspect of the right pulmonary veins. Thirteen of 14 tachycardias (93%) were successfully ablated.ConclusionsLeft AT after CPVA can be due to a macro–re-entrant or focal mechanism. Re-entry occurs most commonly across the mitral isthmus, the posterior wall, or gaps on previous ablation lines. Such gaps and foci occur most commonly at the anterior aspect of the left superior pulmonary vein and at the septal aspect of the right pulmonary veins. These arrhythmias can be successfully mapped and ablated with an electroanatomic mapping system

INAF-Padova-TN-3DPD-SUM

The Team at the Observatory of Padova (INAF) developed a stereo 3d reconstruction pipeline for the planetary images, by taking advantage of its know-how from the design, realization and calibration of the stereo camera STC on board the BepiColombo mission. The stereo cameras STC and CaSSIS are different in terms of optical design and stereo strategy, but they both apply the push-frame acquisition mode. In this context, an ad-hoc DTM generation software, called 3DPD, has been developed.This document describes the nowadays procedures for the internal use of the 3DPD software and the associated MATLAB tools finalized to: - update of the CaSSIS images and spice kernels - Read CaSSIS images data and projection matrices assembly - generate the stereo pair mosaic projects - generate the 3D models (DTMs) - update the OAPD Archive (https://cassis.oapd.inaf.it/archive/) All these procedures can be performed only by OAPD Workstations. Changes in the procedures will be documented in the next issues of this report

Tricyclic pyrazoles: synthesis and biological evaluation of novel 4,5-dihydrobenzo-1h-6-oxa-cyclohepta[1,2-c] pyrazole-based analogues of the cannabinoid antagonist ness 0327

We report in this poster the synthesis and in vitro evaluation of novel 4,5- dihydrobenzo-1H-6-oxa-cyclohepta[1,2-c]pyrazoles 1Cb-l variously substituted in position 3

Unacylated ghrelin prevents mitochondrial dysfunction in a model of ischemia/reperfusion liver injury

Ischemia/reperfusion (I/R) injury is a common cause of liver dysfunction during hepatectomy, liver transplantation procedures and in generalized shock. Although effort has been dedicated to rescuing tissue damage in these clinical settings, there is still an urgent need for an effective treatment to protect the liver from the burden of I/R injury. In this study, we have investigated the potential clinical impact of unacylated-ghrelin (UnAG) in a liver I/R rat model. Particular attention has been paid to mitochondria. We demonstrate that UnAG was able to reduce the lag-phase time in response to ADP administration and increase oxygen consumption in ex vivo experiments using liver mitochondria recovered from rats subjected to I/R. Moreover, we found that UnAG rescued the expression of a key regulator of mitochondrial morphology and electron transport chain function; the optic atrophy 1 (Opa1) protein. Cytochrome c oxidase (COX), ATP synthase (complex V) activity and mitochondrial permeability transition pore (mPTP) opening were also affected by UnAG administration in vivo. An in vitro, hepatic I/R model was used to validate these data. We demonstrate that UnAG upregulates the expression of Cox subunit IV (CoxIV) and increases cellular ATP content. This results in Bcl-2 upregulation and protection against apoptosis. Opa1 silencing shows that Opa1 is crucial for a UnAG-induced increase in cellular ATP content, apoptosis resistance, Bcl-2 and CoxIV expression. Finally, we show that UnAG improves Opa1's interaction with MIC60 in the I/R setting, hinting at its role in cristae shape regulation. Our results demonstrate that UnAG administration rescues the intrinsic mitochondrial pathway triggered by I/R damage. Opa1's contribution in mediating this effect is also reported. This suggests that UnAG can interfere with mitochondrial dysfunction, via Opa1, in a preclinical liver I/R model. We therefore provide the rationale for exploiting UnAG as an alternative means to rescuing mitochondrial damage and organ dysfunction

Estudio de plomo isotópico del lingote depositado en el Museo Minero de Riotinto hallado en Masa Planes (Minas de Riotinto, Huelva - España)

Lead was a necessary element for Roman metallurgical work, so being able to determine its origin is very important to know the commercial circuits of commodities in the Roman world. On February 27th, 2015, a Roman lead ingot was found in Planes Lode (Riotinto Mines, Huelva, Spain), within the area of the Riotinto Project led by Atalaya Mining, we take the opportunity to thank this Company for supporting this Project. It`s the first lead ingot found in Riotinto with a known locationEl plomo fue un elemento necesario para los trabajos metalúrgicos romanos, por lo que poder determinar su origen es muy importante para conocer los circuitos comerciales de las materias primas en el mundo romano. El 27 de febrero de 2015 se encontró un lingote romano de plomo en Masa Planes (Minas de Riotinto, Huelva-España), dentro del área del Proyecto Riotinto liderado por Atalaya Mining, aprovechamos para agradecer a esta compañía el apoyo para este proyecto. Siendo el primer lingote de plomo hallado en Riotinto con una ubicación conocid